Mean values at 3 time points (n=9) Lead CV5RL Difference compared to predose values
Pre-dose 30 min 60 min 30 min 60 min
Control 1.45±0.42 1.41±0.43 1.58±0.25 -0.04 0.13
1.5 mg/kg 1.56±0.41 2.06±0.52 1.79±0.39 0.5* 0.23
6 mg/kg 1.56±0.33 2.16±0.82 1.67±0.58 0.6** 0.11
Change compared to control at 1 mg/kg 0.11 0.65* 0.21    
Change compared to control at 3 mg/kg 0.11 0.75* 0.09    
*: p<0.05; **; p<0.01; ***: p<0.001 (data analyzed with a linear mixed model of analysis of variance with time, dose and the dose*time interaction as fixed effects and animal as a random effect).
Table 3: Effect of cisapride on coefficient of variation of QT in dogs.