| |
Mean values at 3 time points (n=9) Lead CV5RL |
Difference compared to predose values |
| Pre-dose |
30 min |
60 min |
30 min |
60 min |
| Control |
1.45±0.42 |
1.41±0.43 |
1.58±0.25 |
-0.04 |
0.13 |
| 1.5 mg/kg |
1.56±0.41 |
2.06±0.52 |
1.79±0.39 |
0.5* |
0.23 |
| 6 mg/kg |
1.56±0.33 |
2.16±0.82 |
1.67±0.58 |
0.6** |
0.11 |
| Change compared to control at 1 mg/kg |
0.11 |
0.65* |
0.21 |
|
|
| Change compared to control at 3 mg/kg |
0.11 |
0.75* |
0.09 |
|
|
| *: p<0.05; **; p<0.01; ***: p<0.001 (data analyzed with a linear mixed model of analysis of variance with time, dose and the dose*time interaction as fixed effects and animal as a random effect). |
