Figure 3: Group III rat liver received paracetamol at dose of 1 g/kg bw p.o. (paracetamol) showing extensive areas of hepatocellular necrosis and inflammatory cell infiltration. Most of the centrilobular hepatocytes were swollen with marked cytoplasmic vacuolation and pyknotic nuclei with obliterated intervening hepatic sinusoids (H and E x 100).