| Extract |
Growth inhibition (IC50, μg/mL)* |
| Cell line |
| HF6 |
MCF7 |
KB |
PC3 |
HFS-30 |
| B. ariensis Morelos |
6.34 ± 0.02 |
14.22 ± 0.01 |
>20 |
>20 |
4.33 ± 0.02 |
| B. bicolor |
7.29 ± 0.05 |
13.76 ± 0.03 |
>20 |
9.69 ± 0.01 |
>20 |
| B. linanoe |
>20 |
>20 |
13.31 ± 0.05 |
>20 |
>20 |
| B. ariensis México |
1.65 ± 0.03 |
2.49 ± 0.05 |
4.38 ± 0.03 |
>20 |
1.27 ± 0.03 |
| B. glabrifolia Morelos |
>20 |
>20 |
>20 |
>20 |
>20 |
| B. kerberi |
6.97 ± 0.03 |
10.29 ± 0.03 |
>20 |
>20 |
>20 |
| B. glabrifolia Oaxaca |
6.96 ± 0.02 |
7.82 ± 0.01 |
>20 |
>20 |
>20 |
| B. galeottiana |
4.67 ± 0.01 |
4.64 ± 0.02 |
14.26 ± 0.02 |
5.94 ± 0.04 |
9.85 ± 0.01 |
| B. fagaroides |
1.61 ± 0.04 |
2.25 ± 0.01 |
6.29 ± 0.03 |
2.13 ± 0.01 |
0.11 ± 0.03 |
| B. excelsa |
>20 |
>20 |
>20 |
>20 |
>20 |
| B.schlechtendalii |
4.58 ± 0.01 |
9.94 ± 0.02 |
2.13 ± 0.01 |
0.39 ± 0.03 |
7.86 ± 0.01 |
| CTP § |
0.0258 ± 0.02 |
0.0424 ± 0.01 |
0.7855 ± 0.03 |
0.0383 ± 0.02 |
0.5821 ± 0.02 |
| PTOX § |
5.3127E-04 ± 0.01 |
3.7453E-03 ± 0.02 |
4.3833E-04 ± 0.01 |
1.5584E-03 ± 0.01 |
2.82E-02 ± 0.03 |
| *IC50 is defined as the concentration that resulted in a 50% decrease in cell number, and the results are means±standard deviations of three independent replicates. Values greater than 20 μg/mL are considered to be non-cytotoxic. § Positive control substances. The cytotoxic effect was investigated on the human cancer cell lines: nasopharyngeal (KB), colon (HF-6), breast (MCF-7), and prostate (PC-3), as well as on a normal fibroblast cell line (HFS-30) |
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