Extract Growth inhibition (IC50, μg/mL)*
Cell line
HF6 MCF7 KB PC3 HFS-30
B. ariensis Morelos 6.34 ± 0.02 14.22 ± 0.01 >20 >20 4.33 ± 0.02
B. bicolor 7.29 ± 0.05 13.76 ± 0.03 >20 9.69 ± 0.01 >20
B. linanoe >20 >20 13.31 ± 0.05 >20 >20
B. ariensis México 1.65 ± 0.03 2.49 ± 0.05 4.38 ± 0.03 >20 1.27 ± 0.03
B. glabrifolia Morelos >20 >20 >20 >20 >20
B. kerberi 6.97 ± 0.03 10.29 ± 0.03 >20 >20 >20
B. glabrifolia Oaxaca 6.96 ± 0.02 7.82 ± 0.01 >20 >20 >20
B. galeottiana 4.67 ± 0.01 4.64 ± 0.02 14.26 ± 0.02 5.94 ± 0.04 9.85 ± 0.01
B. fagaroides 1.61 ± 0.04 2.25 ± 0.01 6.29 ± 0.03 2.13 ± 0.01 0.11 ± 0.03
B. excelsa >20 >20 >20 >20 >20
B.schlechtendalii 4.58 ± 0.01 9.94 ± 0.02 2.13 ± 0.01 0.39 ± 0.03 7.86 ± 0.01
CTP § 0.0258 ± 0.02 0.0424 ± 0.01 0.7855 ± 0.03 0.0383 ± 0.02 0.5821 ± 0.02
PTOX § 5.3127E-04 ± 0.01 3.7453E-03 ± 0.02 4.3833E-04 ± 0.01 1.5584E-03 ± 0.01 2.82E-02 ± 0.03
*IC50 is defined as the concentration that resulted in a 50% decrease in cell number, and the results are means±standard deviations of three independent replicates. Values greater than 20 μg/mL are considered to be non-cytotoxic. § Positive control substances. The cytotoxic effect was investigated on the human cancer cell lines: nasopharyngeal (KB), colon (HF-6), breast (MCF-7), and prostate (PC-3), as well as on a normal fibroblast cell line (HFS-30)
Table 2: Cytotoxicity of hexane extracts of selected Bursera species from Mexico.