| Extract |
Growth inhibition (IC50, μg/mL)* |
| Cell line |
| HF6 |
MCF7 |
KB |
PC3 |
HFS-30 |
| B. ariensis Morelos |
>20 |
>20 |
>20 |
6.78 ± 0.04 |
>20 |
| B. bicolor |
3.90 ± 0.02 |
11.51 ± 0.03 |
>20 |
0.13 ± 0.03 |
>20 |
| B. linanoe |
>20 |
>20 |
>20 |
>20 |
>20 |
| B. ariensis México |
>20 |
>20 |
>20 |
1.87 ± 0.02 |
>20 |
| B. glabrifolia Morelos |
>20 |
>20 |
>20 |
>20 |
>20 |
| B. kerberi |
0.53 ± 0.01 |
1.74 ± 0.03 |
2.93 ± 0.03 |
0.49 ± 0.05 |
>20 |
| B. glabrifolia Oaxaca |
>20 |
>20 |
>20 |
>20 |
>20 |
| B. galeottiana |
3.14 ± 0.04 |
7.25 ± 0.02 |
13.14 ± 0.05 |
2.26 ± 0.04 |
>20 |
| B. fagaroides |
1.46 ± 0.01 |
3.71 ± 0.01 |
0.96 ± 0.03 |
1.62 ± 0.02 |
2.74 ± 0.04 |
| B. excelsa |
>20 |
>20 |
>20 |
>20 |
>20 |
| B. schlechtendalii |
>20 |
>20 |
6.52 |
>20 |
>20 |
| CTP § |
0.0258 ± 0.02 |
0.0424 ± 0.03 |
0.7855 ± 0.01 |
0.0383 ± 0.01 |
0.5821 ± 0.01 |
| PTOX § |
5.3127E-04 ± 0.01 |
3.7453E-03 ± 0.02 |
4.3833E-04 ± 0.02 |
1.5584E-03 ± 0.01 |
2.82E-02 ± 0.02 |
| *IC50 is defined as the concentration that resulted in a 50% decrease in cell number, and the results are means±standard deviation of three independent replicates. Values greater than 20 μg/mL are considered to be non-cytotoxic. § Positive control substances. The cytotoxic effect was investigated on the human cancer cell lines: nasopharyngeal (KB), colon (HF-6), breast (MCF-7), and prostate (PC-3), as well as on a normal fibroblast cell line (HFS-30). |
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