Extract Growth inhibition (IC50, μg/mL)*
Cell line
HF6 MCF7 KB PC3 HFS-30
B. ariensis Morelos >20 >20 >20 6.78 ± 0.04 >20
B. bicolor 3.90 ± 0.02 11.51 ± 0.03 >20 0.13 ± 0.03 >20
B. linanoe >20 >20 >20 >20 >20
B. ariensis México >20 >20 >20 1.87 ± 0.02 >20
B. glabrifolia Morelos >20 >20 >20 >20 >20
B. kerberi 0.53 ± 0.01 1.74 ± 0.03 2.93 ± 0.03 0.49 ± 0.05 >20
B. glabrifolia Oaxaca >20 >20 >20 >20 >20
B. galeottiana 3.14 ± 0.04 7.25 ± 0.02 13.14 ± 0.05 2.26 ± 0.04 >20
B. fagaroides 1.46 ± 0.01 3.71 ± 0.01 0.96 ± 0.03 1.62 ± 0.02 2.74 ± 0.04
B. excelsa >20 >20 >20 >20 >20
B. schlechtendalii >20 >20 6.52 >20 >20
CTP § 0.0258 ± 0.02 0.0424 ± 0.03 0.7855 ± 0.01 0.0383 ± 0.01 0.5821 ± 0.01
PTOX § 5.3127E-04 ± 0.01 3.7453E-03 ± 0.02 4.3833E-04 ± 0.02 1.5584E-03 ± 0.01 2.82E-02 ± 0.02
*IC50 is defined as the concentration that resulted in a 50% decrease in cell number, and the results are means±standard deviation of three independent replicates. Values greater than 20 μg/mL are considered to be non-cytotoxic. § Positive control substances. The cytotoxic effect was investigated on the human cancer cell lines: nasopharyngeal (KB), colon (HF-6), breast (MCF-7), and prostate (PC-3), as well as on a normal fibroblast cell line (HFS-30).
Table 3: Cytotoxicity of chloroform extracts of selected Bursera species from Mexico.