Patient 1 Patient 2 Pre Post Pre Post PC (70-140%) 23.1 8.2 8.2 12.2 PS (60-130%) 95.1 72.0 122.2 94.1 PT (10.7-14.4 s) 11.9 30.3 11.6 12.9 APTT (23.5-35.0 s) 25.9 43.0 26.9 30.0 FBG (2.0-4.0 g/l) 1.62 2.28 2.31 3.49 D-MII (0-0.55 ng/l) 4.72 0.08 - 2.86 INR 1.08 2.02 1.02 2.05

Table 1: Coagulation parameters and PC alteration of the two patients before and after treatment. Pre: Pre-treatment; Post: Post-treatment; PC: Protein C; PS: Protein S; PT: Prothrombin Time; APTT: Activated Partial Thromboplastin Time; INR: International Normalized Ratio.