Figure 1: Salient Features of Liver Biopsy (H & E stains, ×400 magnification). (A) Portal infiltrate composed mainly of lymphocytes with admixed eosinophils. (B) Portal infiltrate composed of lymphocytes and histiocytes surrounding an injured interlobular bile duct with degenerative epithelial changes (arrow). (C) Acidophil bodies representing hepatocyte apoptosis (white arrow); granuloma (black arrow). (D) Bile pigment in lobular hepatocytes; the degree of hepatocellular cholestasis is out of proportion to the lobular injury seen in Figure 1C. Also note small, loosely formed granuloma