Daysafter last intake Loxapine* (ng/ml) 8-OH-loxapine (ng/ml) 8-OH-loxapine /loxapine ratio ** Amoxapine (ng/ml)
Day 7 73.8 36.3 0.49 <5
Day 13 39.4 25.9 0.67 <5
Day 22 13 7.3 0.56 <5
Day 26 10.9 4.4 0.4 <5
Day 32 5.59 1.79 0.32 <5
Day 42 traces traces NA <5
*Therapeutic range: 10-30 ng/ml; **Usual ratio>2; NA: Not Applicable
Table 1: Plasma concentrations of loxapine and its metabolites.