| Daysafter last intake |
Loxapine* (ng/ml) |
8-OH-loxapine (ng/ml) |
8-OH-loxapine /loxapine ratio ** |
Amoxapine (ng/ml) |
| Day 7 |
73.8 |
36.3 |
0.49 |
<5 |
| Day 13 |
39.4 |
25.9 |
0.67 |
<5 |
| Day 22 |
13 |
7.3 |
0.56 |
<5 |
| Day 26 |
10.9 |
4.4 |
0.4 |
<5 |
| Day 32 |
5.59 |
1.79 |
0.32 |
<5 |
| Day 42 |
traces |
traces |
NA |
<5 |
|
| *Therapeutic range: 10-30 ng/ml; **Usual ratio>2; NA: Not Applicable |
| Table 1: Plasma concentrations of loxapine and its metabolites. |