Cell Type ERα Receptor ERβ Receptor Progesterone Receptor HER2/neu p53
MCF-7 [+] [+] [+] [-] [+] (WT)
MCF-12A [+] [-] [-] [+/-] [+/-]
MDA-MB-453 [-] [-] [-] [+] [-]
[+]: Cell line expresses the protein; [-]: Cell line does not express the protein, or expresses at very low levels; [+/-]: Variable data that does not clearly define expression or non-expression. (WT): Wild Type cell line; ERα/ERβ: Estrogen receptor α and β; HER2/neu: Human Epidermal growth factor Receptor 2.
Table 1: Comparison of key proteins expressed in each of the cell lines.