Study groups

Heart rate

Q-T interval

Saline

322.0± 5.9

61.2± 3.6

CAV

267.1± 6.4 **

93.8± 5.2***

CAV+ Tropi

290.2± 5.7 *#

77.2± 2.5 *#

CAV chemotherapy led to bradycardia and Q-T interval prolongation while tropisetron pretreatment could prevent heart rate and ECG changes in CAV+ Tropi group. Values are the mean ± S.E.M of 6 rats. *p< 0.05; **p<0.01; ***p<0.001 compared to saline group. #p< 0.05 compared to CAV group.
Table 1: Effects of tropisetron pretreatment on CAV combination chemotherapyinduced alterations in (A) heart rate and (B) QT interval.