Figure 5: Toxicokinetics of SPX106T in rats
DDDAS model results appear as solid lines. Actual laboratory values for blood serum measurements appear as black dots with error bars. The red line represents disappearance of SPX106T from the gut. The green line represents blood levels of SPX106T. The blue line represents bladder concentrations of SPX106T. The violet line represents elimination of SPX106T (measured externally after elimination). The horizontal axis values are given in hours. The vertical axis units are arbitrary because of the large number of chemicals represented in the graph. Scaling factors were applied to the concentration values in the curves to make them all easily visible in the same graph.
LDL in apo E-/- mice
DDDAS model results appear as solid lines. Compound names are given next to line colors in the legend. Chylomicrons concentrations appear on the red line. VLDL concentrations appear on the orange line. LDL concentrations appear on the pale green line. HDL concentrations appear in a light blue line. IDL concentrations appear in the teal line. Free fatty acid concentrations (FFA) appear with a sky blue line. HDL precursor appears in a dark blue line. Chylomicrons remnants appear in a violent line. Triglycerides appear in a dark red line. Stored fat appears as an orange/red line. The upper right panel labeled “LDL in apo E-/- mice” depicts a steady state in the mice on Western diet. The horizontal axis is given in days. The vertical axis is given in arbitrary units because of the scaling factors that were applied to the concentration values to represent many chemicals on that axis.
DDDAS model predicts drug effect
DDDAS model results appear as solid lines. Compound names are given next to line colors in the legend. Chylomicrons concentrations appear on the red line. VLDL concentrations appear on the orange line. LDL concentrations appear on the pale green line. HDL concentrations appear in a light blue line. IDL concentrations appear in the teal line. Free fatty acid concentrations (FFA) appear with a sky blue line. HDL precursor appears in a dark blue line. Chylomicrons remnants appear in a violent line. Triglycerides appear in a dark red line. Stored fat appears as an orange/red line. This graph shows the effect of a single dose of SPX 106T on the blood values represented in the steady-state model above (upper right panel). The horizontal axis is given in days. The vertical axis is given in arbitrary units because of the scaling factors that were applied to to the concentration values to represent many chemicals on that axis.