| S No |
Eutectic Components (a,b) |
Ratio |
Tm °C (a) |
Tm °C (b) |
Tm °C (e) |
Challenges |
Findings |
| 1 |
Curcumin, Nicotinamide [5] |
1:2 |
181.4 |
128.3 |
110.5 |
Oral route-
Low solubility, poor oral bioavailability |
10-fold faster IDR and 6-times higher AUC compared to crystalline
curcumin. |
| 2 |
Ibuprofen, Thymol [1] |
2:3 |
76.0 |
52.0 [6] |
32.0 |
Transdermal Route-
Limited ability to penetrate the skin |
A flux of 150 mg/ cm / h, 5.9 times the flux from a saturated aqueous solution with
thymol pretreated skin and 12.7 times the flux from a saturated aqueous solution across non-pretreated skin |
| 3 |
Genistein, PEG 460 [7] |
1:24 |
305.0 |
2.0 |
0.2 |
Parentral Route-
Low aqueous solubility, thus formulation difficulty. |
Could help in solubilization of geinstein crystals for injection development. |
| 4 |
Borneol, Menthol
(Active 125I-cobrotoxin and eutectic mixture mixed) [8] |
1:3 |
- |
- |
- |
Nasal Route-
Blood Brain Barrier |
The eutectic mixture of Borneol Menthol, enhanced formulation and passage of active across the blood brain barrier. |
| 5 |
Menthol and Poloxamer 188, Ibuprofen
(Liquid-gel like Suppository) [9] |
1:9 |
- |
- |
- |
Rectal Route-
Low bioavailability |
Higher AUC as compared to a solid suppository. |
Tm: Melting point temperature; E: Eutectic Mixture; IDR: Intrinsic Dissolution Rate; AUC: Area Under Curve; PEG: Poly Ethylene Glycol