LD 50 (mM)
Compound
Epimastigotes
Amastigotes
Host cells
1
0.05
0.5
7.4
2
5
1.5
7
3
1
0.5
2.4
4
5.5
0.8
2.4
5
0.8
1.2
8
6
0.08
3
2.5
7
0.3
0.5
7.8
8
0.09
0.5
7.6
9
0.06
0.8
7.9
10
0.5
1.5
7.4
11
0.5
0.5
7.6
12
0.5
0.5
7.4
13
0.06
1
4.3
14
0.08
0.8
3.5
BZN
0.05
3
20
HU
0.5
0.1
>20
Table 4:
LD50 values (in mM) for epimastigotes of
T. cruzi
(extracellular forms) and amastigotes (intracellular forms) treated with thiosemicarbazone and 4-thiazolidinone (1-14) compounds, HU and Benznidazol.
