LD 50 (mM)
Compound Epimastigotes Amastigotes Host cells
1 0.05 0.5 7.4
2 5 1.5 7
3 1 0.5 2.4
4 5.5 0.8 2.4
5 0.8 1.2 8
6 0.08 3 2.5
7 0.3 0.5 7.8
8 0.09 0.5 7.6
9 0.06 0.8 7.9
10 0.5 1.5 7.4
11 0.5 0.5 7.6
12 0.5 0.5 7.4
13 0.06 1 4.3
14 0.08 0.8 3.5
BZN 0.05 3 20
HU 0.5 0.1 >20
Table 4: LD50 values (in mM) for epimastigotes of T. cruzi (extracellular forms) and amastigotes (intracellular forms) treated with thiosemicarbazone and 4-thiazolidinone (1-14) compounds, HU and Benznidazol.