Table 3

CSM	CYP2A (2A6)	CYP2B (2B4)	CYP2C (2C8)	CYP2D (2D6)
7	Absent	¹⁷⁷NIICSIVF^184(2.4)	¹⁷²CAPCNVIC^179(2.8)	1⁸⁰KAVSN¹⁸⁴
8	¹⁹³YKDKEFLS²⁰⁰	¹⁸⁷RFDYKD1^92(2.2)	¹⁸⁶RFDYKD^191(2.2)	¹⁹²GRRFEYDDP²⁰⁰
9	²¹⁷GQLYEMFSSVM227	²¹⁰SSFSSQVFELFS^221(2.4)	²¹¹PWIQVCNNFP^220(2.2)	²²⁵NAVPVLLHIPALAGK²³⁹
10	Absent	²²⁶HFPGTH^231(2.0)	²²⁵CFPGTH^230(1.8)	Absent
11	²⁶⁰DPNSP264	²⁶¹PRDFIDVY^268(1.6)	²⁶⁰PRDFIDC^266(2.0)	Absent

The number of CYP sequences analyzed for each family is shown in parenthesis
The CYP sequences used from various species are presented earlier (22)
The colors of the residues in the motifs represent the rank order of sequence conservation as a function of relative entropy; red is the least conserved (>75%), black is intermediate (75-90%),
and blue represents the most conserved (>90%)
^aThe rank is shown in parenthesis. The rank of CYP2A and CYP2D are ≤1.2
“Absent” in CYP2A and CYP2D represents lack of their respective CSM based on PCPMer motifs analysis
Residues and their numbers in the motifs for each CYP2 subfamilies are based on the specific CYP indicated in the first row

Table 3: Identification and analysis of PCPMer motifs of CYP2A (12), CYP2B (10), CYP2C (33), and CYP2D (25) enzymes in the E-H region.