CYPs |
CSM 7 |
CSM 8 |
CSM 10 |
CSM 11 |
1A1 |
166EAEVLISTLQ175 |
183HFNPYRY189 |
224FGEVVGSG231 |
251FKDLNEKFYSF261 |
1A2 |
168EAKALISRLQ177 |
185HFDPYNQ190 |
226FVETASSQ232 |
253FKAFNQRFLWF263 |
2A6 |
177TVSNVIS183 |
190RFDYKD195 |
229HLPGPQ234 |
264PRDFIDS270 |
2A7 |
177TVSNVIS183 |
190RFDYED195 |
229HVPGPQ234 |
264PRDFIDS270 |
2A13 |
177CVSNVIC183 |
190RFEYAN195 |
229HVPGPH234 |
264PRDLIDS270 |
2B6 |
173ITANIIC180 |
187RFHYQD192 |
226YFPGAH231 |
261PKDLIDT267 |
2C8 |
172CAPCNVIC179 |
186RFDYKD191 |
225CFPGTH230 |
260PRDFMDC266 |
2C9 |
172CAPCNVIC179 |
186RFDYKD191 |
225YFPGTH230 |
260PQDFIDC266 |
2C18 |
172CAPCNVIC179 |
186RFDYKD191 |
225YLPGSH230 |
260ARDFIDC266 |
2C19 |
172CAPCNVIC179 |
186RFDFLD191 |
225YFPGTH230 |
268PRDFIDC274 |
2D6 |
180KAVSNVIA187 |
194RFEYDD199 |
232HIPALA237 |
217PRDLTEA223 |
2E1 |
174CAPYNVIA181 |
188HFDYND193 |
227YLPGSH232 |
262PRDLTDC268 |
3A4 |
189FGVNIDS195 |
212RFDFLD217 |
224IVFPFL229 |
258ESRLEDT264 |
3A5 |
189FGVNIDS195 |
212KFGFLD217 |
224ILFPFL229 |
258KSRLNDK264 |
3A7 |
189FGVSIDS195 |
212RFNPLD217 |
224KVFPFL229 |
258EGRLKET264 |
The CSM in all the CYPs is based on PCPMer motifs identified in the respective CYP1, CYP2, and CYP3 families (Table 2)
The colors of the residues in the motifs represent the rank order of sequence conservation as a function of relative entropy; red is the least conserved (>75%), black is
intermediate (75-90%), and blue represents the most conserved (>90%) The order of residues conservation was determined manually using the known CYP sequences from various species in the respective families; 1A, 2A, 2B, 2C, 2D, 2E,
and 3A
CSM 9 is not shown because it is not found in CYP1 and CYP3 families and is least conserved in CYP2 family |
