Table 2b

Tissue (µg eq/g) n=3		Oral (time after first dose) 6					Transdermal (time after application)
Tissue (µg eq/g) n=3		168h	192h	216h	312h	504h	168h	192h	216h	312h	504h
Blood/Plasma		LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ
Adrenal Gland		0.47	0.42	0.15	0.26	LOQ	1.75	1.54	LOQ	LOQ	0.61
Aorta		0.65	0.20	LOQ	0.22	LOQ	LOQ	LOQ	LOQ	13.74	LOQ
Eye		163.40	157.21	172.44	112.49	92.14	76.23	118.61	67.65	42.56	21.49
Liver		1.30	0.36	0.11	LOQ	LOQ	1.98	2.08	0.60	LOQ	LOQ
Pituitary		LOQ	1.96	LOQ	0.86	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ
Stomach		0.28	LOQ	LOQ	LOQ	LOQ	0.25	0.15	LOQ	LOQ	LOQ
Small Intestine		0.86	LOQ	LOQ	LOQ	LOQ	1.10	0.66	0.14	LOQ	LOQ
Large Intestine		1.32	LOQ	LOQ	LOQ	LOQ	0.87	0.75	0.16	LOQ	LOQ
Skin-Pigmented		11.44	25.68	31.05	9.64	8.32	14.87	7.76	4.51	4.36	2.76
Skin-Unpigmented		0.52	LOQ	LOQ	LOQ	0.75	0.39	0.58	LOQ	LOQ	LOQ
Thyroid/Parathyroid		LOQ	0.64	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ
Dose Site	Pigmented	NA					72.04	8.69	23.77	8.49	LOQ
Dose Site	Unpigmented	NA					88.91	8.37	10.31	4.99	1.86
Stratum Corneum7		NA					12.70	2.92	2.49	0.65	0.49

LOQ = below limit of quantitation; NA = not applicable to route of administration
6 Days 1 and 2 – 30 mg/kg; days 3-7, 10 mg/kg; oral gavage
7 Expressed as per cent of dose (mean dose of 42.4 mg/kg)

Table 2b: Mean Radioactivity in Blood, Plasma, Selected Tissues and Stratum Corneum (Transdermal only) from Long-Evans Rats Administered a Repeated Oral
¹⁴C-Donepezil or 7-Day Transdermal Patch Containing ¹⁴C-Donepezil.