Period

Parameters

Control
X ± SD

4-CPA 10 ppm
X ± SD

4-CPA 20 ppm
X ± SD

SUBACUTE

 

SOD U/ml

2204.1 ± 22.1

2184.7 ± 36.9

2162.6 ± 20.7*

GR U/ml

0.9 ± 0.03

1.0 ± 0.02*

0.8 ± 0.07*

CAT U/ml

108.0 ± 5.8

88.3 ± 9.3*

59.2 ± 9.7*

GPx U/ml

348.7 ± 13.8

215.5 ± 11.2*

231.5 ± 9.3*

GST U/ml

4.4 ± 0.3

3.6 ± 0.2*

2.4 ± 0.2*

G6PD

0.9 ± 0.01

1.0 ± 0.08*

0.9 ± 0.06

GSH mg/dl

17.0 ± 0.8

13.8 ± 0.8*

10.8 ± 0.8*

MDA nmol/ml

10.0 ± 0.5

14.3 ± 1.0*

21.4 ± 1.5*

 

 

 

 

 

SUBCHRONIC

 

SOD U/ml

2278.5 ± 13.0

2258.7 ± 24.1

2263.5 ± 21.7

GR U/ml

0.9 ± 0.1

0.7 ± 0.05

0.5 ± 0.08*

CAT U/ml

107.6 ± 17.7

160.3 ± 20.1*

148.3 ± 26.3*

GPx U/ml

431.0 ± 11.3

377.9 ± 7.5*

373.5 ± 8.3*

GST U/ml

4.1 ± 0.3

0.3 ± 0.05*

0.9 ± 0.05*

G6PD

1.0 ± 0.05

1.1 ± 0.04

1.0 ± 0.07

GSH mg/dl

18.3 ± 0.4

16.6 ± 0.4*

16.7 ± 0.7*

MDA nmol/ml

9.1 ± 0.5

34.4 ± 2.1*

49.5 ± 2.6*

Each value represents the Mean ± SD. * p<0.05
Table 12: Effects of 4-CPA 10-20 ppm on antioxidant defence systems and MDA contents in brain of rats at subacute and subchronic.