Species

Time points
(min)

Average % drug remaining
(Mean ± S.D.)

Average % drug metabolized
(Mean ± S.D.)

Human

0
15

100
88.03±2.0

0
11.97±4.65

30

74.28 ± 2.74

25.72 ± 2.06

60

52.90 ± 2.76

47.10 ± 3.56

Rat
(Wistar)

0

100

0

15

10.38 ± 3.53

89.62 ± 3.52

30

6.15 ± 2.99

93.85 ± 0.79

60

5.01 ± 2.61

94.99 ± 0.14

Mouse
(CD 1)

0

100

0

15

39.00 ± 3.59

61.00 ± 4.08

30

25.02 ± 0.72

74.98 ± 3.13

60

18.68 ± 1.27

81.32 ± 0.33

Dog
(Beagle)

0
15
30

100
80.15± 0.23
68.99 ±0.01

0
19.85 ±1.26
31.01±0.61

60

66.02 ± 2.0

33.98 ± 0.80

Table 5: Metabolic stability data of Imipramine in different species.