Type of Microsomes

Age & Sex of the Animals

Enzymes Present

Specific activity P-450 (pmole /mg)

Pooled Human Liver Microsomes (HLM)

Pool of liver from 24
(Male and Female)
donors  24-77 years of Age

CYP1A2

300

CYP3A4

CYP2C9

CYP2D6

Pooled Rat Liver Microsomes Wister Han (RLM)

Pool of liver from
17 male rats, 8-10 weeks of  Age

CYP1A2

820

CYP3A4

CYP2C9

CYP2D6

Pooled Mouse Liver Microsomes
CD1 (MLM)

Pool of liver from 
8 male mice, 11 weeks of  Age

CYP1A2

740

CYP3A4

CYP2E1

CYP4A11

Pooled Dog Liver Microsomes Beagle  (DLM)

Pool of liver from
4 male dogs, aged ≥ 12 months

CYP1A2

260

CYP3A4

CYP2C9

CYP4A11

(Information provided by BD GentestTM , Woburn, MA 01801)
Table 7: Details of Microsomes and CYP-450 enzyme specific activity.