Pre

after HbV administration

(hour)

(day)

1

6

1

3

7

14

Systolic blood pressure (mmHg)

Ave.
(range)

118.5 ± 8.3
(110-130)

124.5 ± 4.7
(120-129)

123.3 ± 15.4
(103-139)

109.3 ± 11.1
(99-125)

110.5 ± 14.3
(94-129)

104.3 ± 10.3
(93-114)

109 ± 10.1
(101-122)

Diastolic blood pressure (mmHg)

Ave.
(range)

64.3±4.9
(58-70)

66.8±5.7
(60-72)

66.3±6.6
(57-71)

56.3±9.1
(48-69)

63.3±10.0
(53-77)

56.5±5.1
(53-64)

55.3±6.1
(50-64)

Data are mean ± S.D. (n=4)
Table 2: Changes in mean systolic and diastolic blood pressure after hemoglobin-vesicle administration at a dose of 1400 mg Hb/kg in male cynomolgus monkeys.