pre

Day after HbV administration

7

14

Sodium (mEq/dL)

Ave. (range)

153.9±1.5 (152-155)

146.9±2.1 (145-152)

148.7±2.4 (144-150)

Pottasium (mEq/dL)

Ave. (range)

4.3±0.5 (3.6-4.7)

3.9±0.2 (4.1-5.1)

4.4±0.4 (3.7-4.4)

Calcium (mEq/dL)

Ave. (range)

10.3±1.5 (8.3-12.0)

10.8±1.7 (8.3-11.3)

9.9±1.4 (9.4-12.9)

Chloride (mEq/dL)

Ave. (range)

112.2±2.0 (111-115)

108.8±1.8 (107-115)

112.4±3.6 (106-111)

Glucose (mg/dL)

Ave. (range)

91.8±24.4 (72-122)

91.5±10.2 (70-127)

91.0±24.9 (80-102)

Inorganic phosphate (mg/dL)

Ave. (range)

5.2±0.9 (4.0-5.9)

5.7±0.7 (5.0-6.6)

6.0±0.8** (4.7-6.4)

** p<0.01 vs. pre-treatment. Data are mean ± S.D. (n=4)
Table 4: Summary of electrolytes after hemoglobin-vesicle administration at a dose of 1400 mg Hb/kg in male cynomolgus monkeys.