Groups

  Plasma

Liver

Kidney

    SGOT

SGPT

Creatinine

ALP

SGOT

SGPT

Creatinine

Control group

 10.10 ±  2.45

12.97  ± 2.63

1.02 ± 0.12

19.56 ±  3.54

20.48  ±  0.85

8.63 ±  1.21

0.86  ±  0.053

Cadmium exposed group

 88.56 ±  4.56***

115.12  ± 1.07***

7.54  ± 1.75***

5.98 ±  0.63***

73.63 ±  1.55***

35.28 ± 2.01***

5.84 ± 0.13***

Ceftriaxone plus sulbactam with VRP1034 treated group

 34.12 ±  5.47***

66.39  ± 3.25***

3.23  ±  0.22***

14.25 ±  1.14***

41.21 ±  0.99***

18.56  ±  2.84***

1.96  ± 0.22***
All data are Mean ± SD of each group. These parameters were expressed in the plasma (IU/L) whereas in the tissues (mMole/gm tissue). Newman keuls test was performed for statistical significance between control group vs Cd exposed group and Cd exposed group vs ceftriaxone plus sulbactam with VRP1034 treated group. Where ***p<0.001 (highly significant) **p<0.01(significant); *p<0.05 (significant) Nsp>0.05 (non significant).
Table 5: Effect of ceftriaxone plus sulbactam with VRP1034 on hepatic and renal parameters in cadmium exposed group after 21 days treatment.