Fraction Retention Time Metabolite as % Dose Metabolite Names 1 2.8 3.11 Unknown glucuronide conjugate 2 3.2 4.30 Unknown glucuronide conjugate 3 3.7 5.06 Metabolite 17 -Glucuronide of M6 4 4.3 4.56 Metabolite 14 -Glucuronde of M5 5 5.8 6.43 Metabolite 8 -Glucuronide of M7 6 7.8 2.37 Metabolite 11 -Glucronide of M1a 7 8.1 2.54 Metabolite 18 -Sulphate of M5 8 9.5 14.58 Metabolite 10 -Glucuronide of M1b 9 10.3 2.32 Metabolite 15 -Glucuronide of M12 10 13.2 4.06 Unknown 11 20.1 2.80 Metabolite 16 -Sulphate of M12 12 23.2 0.97 Metabolite 1a 13 24.9 0.41 Metabolite 1b Consistent with Reference Standard M1 Identified % of urinary radioactivity 92.41 Unidentified % of urinary radioactivity 7.59 Identified % of dose 49.44 Unidentified % of dose 4.06 M3 – Only observed in deconjugated samples as a trace component. The conjugate of M3 was not identified. M9 – Retention time 19 minutes. Trace component M13 – Retention time at 17 min. Trace component.

Table 3: The Assignment of Peaks in 0-24 h Urine.