Parameter
Experimental Calves
Mean ± S.E.M.
C1
C2
C3
C4
C5
C6
A
1
(mg/ml)
80.16
69.02
79.91
69.30
80.11
80.24
76.45 ± 2.30
A
2
(mg/ml)
8.91
8.48
8.75
8.49
8.82
8.80
8.7 ± 0.073
B (mg/ml)
10.44
10.38
10.25
10.40
10.45
10.50
10.40 ± 0.035
β (h
-1
)
0.11
0.11
0.10
0.12
0.11
0.13
0.11 ± 0.004
α
1
(h
-1
)
11.39
11.39
11.10
11.21
11.4
11.11
11.26 ± 0.058
α
2
(h
-1
)
0.18
0.19
0.20
0.19
0.17
0.20
0.18 ± 0.004
t
1/2
α
1
(h)
0.060
0.060
0.062
0.061
0.060
0.062
0.060 ± 0.0004
t
1/2
α
2
(h)
3.85
3.64
3.46
3.64
4.07
3.45
3.99 ± 0.27
t
1/2
β (h)
6.3
6.3
6.9
5.77
6.30
5.33
6.15 ± 0.21
AUC(mg/ml.h)
151.43
145.04
153.44
137.52
153.9
131.98
145.55 ± 3.72
AUMC (mg/ml.h
2
)
1149.04
1093.3
1244.39
957.95
1169.43
841.95
1076.1 ± 60.94
MRT (h)
7.58
7.53
8.10
6.96
7.59
6.37
7.35 ± 0.24
Kel (h
-1
)
0.65
0.60
0.64
0.64
0.64
0.75
0.65 ± 0.020
T ≈ P
5.25
4.55
4.66
4.55
4.88
4.88
4.96 ± 0.17
Vd
area
(L/kg)
0.60
0.62
0.65
0.60
0.59
0.58
0.60 ± 0.010
Cl
B
(L/kg/h)
0.066
0.068
0.065
0.072
0.064
0.075
0.068 ± 0.0017
Table 1
: Pharmacokinetic parameters of Amikacin (10 mg/kg, i.v.) and
W. somnifera
(500 mg/kg,orally) after combined administration in Buffalo calves (n=6).
