Exposure Gender Rat Columnar pithelial cell Macrophage Neutrophil Lymphocyte
Air Male 1
2
3
4
5
6
7
8
2+
+
+
+
+
+
-
+
3+
4+
2+
4+
+
-
+
3+
-
-
-
-
-
-
-
+
-
-
-
+
-
-
-
-
Air Female 9
10
11
12
13
14
15
16
2+
+
+
+
+
+
+
+
4+
2+
+
3+
2+
2+
+
2+
+
-
-
+
-
-
-
-
-
+
-
-
-
-
-
-
ClO2 Male 17
18
19
20
21
22
23
24
+
+
2+
-
+
+
-
+
4+
4+
5+
5+
2+
3+
+
3+
-
-
-
-
-
-
-
-
-
-
-
-
-
+
-
-
ClO2 Female 25
26
27
28
29
30
31
32
+
+
+
+
+
-
+
+
-
2+
2+
3+
2+
2+
2+
2+
-
-
-
-
-
-
+
-
-
-
-
-
-
-
-
-
The extent of inflammatory changes observed was graded from – to 5+ by a single examiner. Differences between the ClO2- and air-exposed groups, evaluated by Mann-Whitney U-test, were statistically not significant
Table 2: Analysis of broncho-alveolar lavage fluid (BALF) of the ClO2- and air-exposed rats obtained at necropsy.