| Exposure |
Gender |
Rat |
Columnar pithelial cell |
Macrophage |
Neutrophil |
Lymphocyte |
| Air |
Male |
1
2
3
4
5
6
7
8 |
2+
+
+
+
+
+
-
+ |
3+
4+
2+
4+
+
-
+
3+ |
-
-
-
-
-
-
-
+ |
-
-
-
+
-
-
-
- |
| Air |
Female |
9
10
11
12
13
14
15
16 |
2+
+
+
+
+
+
+
+ |
4+
2+
+
3+
2+
2+
+
2+ |
+
-
-
+
-
-
-
- |
-
+
-
-
-
-
-
- |
| ClO2 |
Male |
17
18
19
20
21
22
23
24 |
+
+
2+
-
+
+
-
+ |
4+
4+
5+
5+
2+
3+
+
3+ |
-
-
-
-
-
-
-
- |
-
-
-
-
-
+
-
- |
| ClO2 |
Female |
25
26
27
28
29
30
31
32 |
+
+
+
+
+
-
+
+ |
-
2+
2+
3+
2+
2+
2+
2+ |
-
-
-
-
-
-
+
- |
-
-
-
-
-
-
-
- |
The extent of inflammatory changes observed was graded from – to 5+ by a single examiner. Differences between the ClO2- and air-exposed groups, evaluated by Mann-Whitney U-test, were statistically not significant |
