| Attributes |
Pharmacopoeial reference |
Test method |
Specification |
| Pyridostigmine bromide tablet |
Potassium iodate tablet |
| Weight uniformity |
BP Vol. IV (Appendix XII C/A3 02, 2008) |
% error of each tablet from average weight |
<5% |
<5% |
| Dissolution time |
BP Vol. IV (Appendix XII B/A2 86-88, 2008) |
Basket type Dissolution test apparatus |
T80% 60 min |
t75% 15 min |
| Disintegration time |
BP Vol. IV (Appendix XII A/A2 83, 2008) |
Disintegration test apparatus |
≥ 15 min |
≥ 15 min |
| Hardness test |
BP Vol. IV (Appendix XVII H/A4 24, 2008) |
“Monsanto” Tablet hardness tester |
≥ 70 N |
≥ 70 N |
| Friability test |
BP Vol. IV (Appendix XVII G/A4 23, 2008) |
BP standard tablet friability tester |
≤ 1% |
≤ 1% |
| Moister content |
Not in Monograph (Musa et al., 2008) |
Water absorption ratio |
>10% |
>10% |
| Pyridostigmine Bromide Assay |
Waehler et al. 1993 [24]
BP Vol. II (Page no. 1785, 1980) |
HPLC (% LC)
And Titrametry |
95.0-105.0% |
95.0-105.0% |
| Potassium Iodate Assay |
BP Vol. II (Page no. 1785, 2008) |
Titrametry |
95.0-105.0% |
95.0-105.0% |
