| Day |
Treatment (mg/kg, p.o) |
SGOT (IU/L) M ± SEM |
SGPT (IU/L) M ± SEM |
ALP (U/l) M ± SEM |
Cholesterol (mg/dl) M ± SEM |
Triglyceride (mg/dl) M ± SEM |
Protein (gm/dl) M ± SEM |
HDL (mg/dl) M ± SEM |
LDL (mg/dl) M ± SEM |
Glucose (gm/dl) M ± SEM |
| 45 |
Vehicle control |
44.72 ± 2.66 |
42.21 ± 3.15 |
105.74 ± 4.34 |
119.70 ± 3.22 |
63.50 ± 3.70 |
7.63 ± 0.14 |
40.67 ± 2.86 |
76.33 ± 2.11 |
109.72 ± 5.30 |
| Pyridostigmine (20) |
47.23 ± 2.29ns |
44.25 ± 2.56ns |
112.49 ± 3.04ns |
126.86 ± 5.75ns |
116.90 ± 5.10*** |
7.95 ± 0.81ns |
39.06 ± 2.76ns |
76.42 ± 3.14ns |
110.26 ± 2.88ns |
| Pyridostigmine (30) |
56.46 ± 3.73ns |
52.87 ± 2.64ns |
120.80 ± 3.50* |
141.32 ± 5.16** |
146.97 ± 5.22*** |
9.55 ± 0.68ns |
38.77 ± 3.22ns |
3.15 ± 3.82ns |
115.80 ± 3.03ns |
| Pyridostigmine (45) |
62.72 ± 3.45** |
54.24 ± 3.11* |
132.56 ± 4.33*** |
150.87 ± 5.12*** |
161.15 ± 3.33*** |
10.08 ± 1.23ns |
27.34 ± 1.12** |
91.30 ± 3.56* |
120.03 ± 3.25ns |
|
| n=10. *P<0.05, **P<0.01, ***P<0.001 and ns=not significant when compared to respective control group |
| Table 5: Effect of daily oral administration of Pyridostigmine Bromide tablet up to 45 days on serum biochemical parameters of rat. |
