Parameters Rat Human
Number of hepatocytes/g liver (cells/g liver) 120×106 120×106
Liver weight/kg body weight (g liver/kg) 40 25.7
Liver blood flow (ml/min/kg) 55.2 20.7
Data from Bayliss et al. (1999) (11) and Davies and Morris (1993) (12).
Table 1: Physiological parameters for calculation of intrinsic clearance in rat and human.