Parameters
Rat
Human
Number of hepatocytes/g liver (cells/g liver)
120×10
6
120×10
6
Liver weight/kg body weight (g liver/kg)
40
25.7
Liver blood flow (ml/min/kg)
55.2
20.7
Data from Bayliss et al. (1999) (11) and Davies and Morris (1993) (12).
Table 1:
Physiological parameters for calculation of intrinsic clearance in rat and human.
