Plasma
  Low Medium High
Theoretical (ng/ml) 31.25 125 1000
% Bias-inter day -3.12 -2.15 3.51
% Bias-intra day -12.52 -0.12 8.61
% CV-inter day 10.91 3.31 1.21
% CV-intra day 1.20 13.51 10.24
S9
Theoretical (ng/ml) 62.5 500 2000
% Bias-inter day -5.12 -8.91 1.12
% Bias-intra day -7.42 -3.56 11.25
% CV-inter day -2.34 -8.57 10.14
% CV-intra day -5.16 -3.46 9.21
Urine
Theoretical (ng/ml) 80 200 500
% Bias-inter day 0.25 -0.4 2.5
% Bias-intra day 1.59 -2.1 1
% CV-inter day 3.4 3.4 1.8
% CV-intra day 9.9 7.7 6.7
Feces
Theoretical (ng/ml) 100 200 500
% Bias-inter day -7.41 -6.8 -3.2
% Bias-intra day -8.29 -7.2 8.61
% CV-inter day 13.9 5.8 3.6
% CV-intra day 8.5 5.7 9.9
Table 2: Validation of CDRI-80/574 in S9, plasma, urine and feces of normal Sprague-Dawley rats.