Time (min) CDRI 80-574 (% remaining)
Rat Hepatocytes Human Hepatocytes
0 100 100
5 75 79
10 40 55
15 20 42
20 11 29
30 0 10
Values are mean of three independent sets of experiments
Table 5: Metabolic Stability of CDRI-80/574 in Rat and Human Hepatocytes.