Inhibitors Concentration (μM) CYP(s) Isoforms % CDRI-80/574 metabolism Metabolite(s)
Ketoconazole 2.50 3A4, 5, 7 12.95 Nil
Diltiazem 0.25 3A4, 5, 7 10.49 Nil
Quinidine 2.50 2D6 95.10 Two
Sulfaphenazole 0.50 2C9 22.66 Two
Chlorozoxazone 0.25 2E1 53.79 Two
Isoniazid 2.50 2C9 82.07 Two
Cimitidine 2.50 1A2 54.83 Two
Floxetine 0.25 2C19 52.26 Two
Coumarin 0.25 2A6 52.96 Two
Aminobenzotriazole 1.0 all Nil Nil
Values are average of two different sets of experiments
Table 7: Effect of different CYP450 isoform inhibitors.