| Inhibitors |
Concentration
(μM) |
CYP(s) Isoforms |
% CDRI-80/574
metabolism |
Metabolite(s) |
| Ketoconazole |
2.50 |
3A4, 5, 7 |
12.95 |
Nil |
| Diltiazem |
0.25 |
3A4, 5, 7 |
10.49 |
Nil |
| Quinidine |
2.50 |
2D6 |
95.10 |
Two |
| Sulfaphenazole |
0.50 |
2C9 |
22.66 |
Two |
| Chlorozoxazone |
0.25 |
2E1 |
53.79 |
Two |
| Isoniazid |
2.50 |
2C9 |
82.07 |
Two |
| Cimitidine |
2.50 |
1A2 |
54.83 |
Two |
| Floxetine |
0.25 |
2C19 |
52.26 |
Two |
| Coumarin |
0.25 |
2A6 |
52.96 |
Two |
| Aminobenzotriazole |
1.0 |
all |
Nil |
Nil |
Values are average of two different sets of experiments |
