Time (min) S9 (0.9μg/ml) S9 (1.8μg/ml) Microsomes (0.45μg/ml) CDRI-80/574 Epoxy CDRI-80/574 Epoxy CDRI-80/574 Epoxy 0 100 0 100 0 100 0 15 64 30 47 50 35 68 30 51 45 30 65 20 79 45 10 80 25 77 12 84 60 0 100 3 100 0 100 75 0 71 0 84 0 82 120 0 62 0 70 0 68 150 0 62 0 70 0 0 Values are mean of three separate sets of experiments

Table 9: Formation of epoxy metabolite from CDRI-80/574 in hepatic S9 (2 protein concentrations) and microsomal fraction of male Sprague Dawley rat.