Parameters iv treatment Oral treatment Oral Treatment after grapefruit juice
Cmax (μg/L) - 250.0 ± 45.1 791.4 ± 19.2
Tmax (h) - 1.5 1.5
AUClast (μg.h/L) 1386 ± 371.21 784.1 ± 48.1 1287.1 ± 84.8
T1/2 (min) 18.7 ± 1.20    
Vz (L) 2.02 ± 0.21    
Cl (L/h/kg) 7.49 ± 1.59    
MRT (min) 28.66 140 258
%F   7  
Values are mean ± SD of 6 rats
Table 11: Pharmacokinetics Profile of CDRI-80/574 after pretreatment with grapefruit juice.