| Parameters |
iv treatment |
Oral treatment |
Oral Treatment after grapefruit juice |
| Cmax (μg/L) |
- |
250.0 ± 45.1 |
791.4 ± 19.2 |
| Tmax (h) |
- |
1.5 |
1.5 |
| AUClast (μg.h/L) |
1386 ± 371.21 |
784.1 ± 48.1 |
1287.1 ± 84.8 |
| T1/2 (min) |
18.7 ± 1.20 |
|
|
| Vz (L) |
2.02 ± 0.21 |
|
|
| Cl (L/h/kg) |
7.49 ± 1.59 |
|
|
| MRT (min) |
28.66 |
140 |
258 |
| %F |
|
7 |
|
Values are mean ± SD of 6 rats |
