Drugs % F Urinary excretion % Plasma Protein Binding % Cl (ml/min/ kg) Vd (liters/kg) Half-life (hr)
Gemfibrozil 98 ± 1 < 1 > 97 1.7 ± 0.4 0.14 ± 0.03 1.1 ± 0.02
Lovastatin < 5 Negligible 95 4-18 - 1.1-1.7
Pravastatin 18 ± 8 47 ± 7 43-48 3.5 ± 2.4 0.46 ± 0.04 1.8 ± 0.8
Simvastatin < 5 Negligible 94 7.6 - 1.9
Clofibrate 95 ± 10 57 ± 2 .1 96.5 ± 0.3 0.12 ±.01 0.11 ± 0.02 13 ± 3
Table 12: HumanPharmacokinetic profile of some current hypolipidemic drugs.