Parameters
DADS
AM
AMS
AMSO
AMSO
2
t
1/2
(h)
ND
a
4.39
6.78
7.16
8.64
C
max
(mM L
-1
)
0.001
0.008
0.008
0.376
1.440
T
max
(h)
< 1
b
24
24
48
48
AUCtotal (h mM L
-1
)
ND
0.324
0.328
23.75
116.86
Clp (L h
-1
)
ND
1.475
1.455
0.020
0.004
* Adopted from the work by Germain et al. (2002)
a
ND: not determined;
b
Estimated value
Table 2:
Pharmacokinetic parameters of DADS and its metabolites after a single oral administration of 200 mg Kg
-1
in rats.*
