Parameters DADS AM AMS AMSO AMSO2
t1/2 (h) NDa 4.39 6.78 7.16 8.64
Cmax (mM L-1) 0.001 0.008 0.008 0.376 1.440
Tmax (h) < 1b 24 24 48 48
AUCtotal (h mM L-1) ND 0.324 0.328 23.75 116.86
Clp (L h-1) ND 1.475 1.455 0.020 0.004
* Adopted from the work by Germain et al. (2002)
a ND: not determined;
b Estimated value
Table 2: Pharmacokinetic parameters of DADS and its metabolites after a single oral administration of 200 mg Kg-1 in rats.*