Figure 5 : The effect of imeglimin (0.125–1.5 mmol•L-1) on gluconeogenesis was studied in primary rat hepatocyte cultures as described in Methods. Results are the mean values of five wells each. Imeglimin significantly inhibited glucose production (**P<0.01) at doses from 0.25–1.5 mmol•L-1 when compared with controls.