Characteristics Low GPx activity (n=34) High GPx activity (n=25) P value Beta value 1 -Beta (%) Total blood glutathione (pmol/µg protein)1 50 ± 3 40 ± 2 <0.001     GPx (nmol/min/mg protein) 1.43 ± 0.04 2.59 ± 0.07 <0.001     GSSG-R (pmol/min/mg protein) 124 ± 5 141 ± 10 0.11 0.813 19 GPx/GSSG-R 12 ± 1 21 ± 2 <0.001     Mean ± SEM GPx: glutathione peroxidase (specific activity), GSSG-R: glutathione reductase (specific activity 1whole cohort: n=49, Low GPx activity: n=30, High GPx activity: n=19

Table 1: Glutathione metabolism of the subjects with either low or high GPx activity.