| Characteristics |
Low GPx activity (n=34) |
High GPx activity (n=25) |
P
value |
Beta value |
1 -Beta
(%) |
| Age (years) |
56 ± 1 |
56 ± 1 |
0.92 |
0.03 |
97 |
| Body weight (kg) |
91 ± 2 |
91 ± 3 |
1.00 |
0.03 |
97 |
| BMI (kg/m2) |
34.5 ± 0.5 |
34.6 ± 0.6 |
0.85 |
0.03 |
97 |
| Systolic BP (mm Hg) |
125 ± 3 |
126 ± 3 |
0.73 |
0.04 |
96 |
| Diastolic BP (mm Hg) |
79 ± 3 |
79 ± 1 |
0.96 |
0.03 |
97 |
| Blood lipids and apolipoproteins |
|
|
|
|
|
| Cholesterol (mmol/L) |
5.21 ± 0.15 |
5.57 ± 0.18 |
0.13 |
0.66 |
34 |
| LDL-C (mmol/L)1 |
3.09 ± 0.14 |
3.41 ± 0.17 |
0.15 |
0.56 |
44 |
| HDL-C (mmol/L) |
1.52 ± 0.05 |
1.48 ± 0.06 |
0.67 |
0.08 |
92 |
| Triglycerides (mmol/L)1 |
1.30 ± 0.09 |
1.32 ± 0.09 |
0.33 |
0.04 |
96 |
| apoB (g/L) |
0.89 ± 0.04 |
1.02 ± 0.03 |
0.02 |
|
|
| Glucose status |
|
|
|
|
|
| Fasting glycemia (mmol/L) |
5.4 ± 0.1 |
5.7 ± 0.1 |
0.13 |
0.80 |
20 |
| Fasting insulinemia (µU/mL)2 |
16.1 ± 1.2 |
17.7 ± 1.6 |
0.41 |
0.15 |
85 |
| HOMA-IR |
3.48 ± 0.29 |
4.83 ± 0.60 |
0.04 |
|
|
| Liver insulin resistance index (x104) |
29.3 ± 2.4 |
39.0 ± 4.0 |
0.03 |
|
|
| SIisOGTT |
0.263 ± 0.003 |
0.257 ± 0.004 |
0.18 |
0.34 |
66 |
| Glucose disposal (mg/min/kg) |
12.5 ± 0.7 |
11.6 ± 0.9 |
0.38 |
0.16 |
84 |
| Serum inflammatory markers |
|
|
|
|
|
| IL-6 (pg/mL) |
1.7 ± 0.2 |
1.6 ± 0.7 |
0.65 |
0.04 |
94 |
| hsCRP (mg/L)3 |
4.4 ± 0.5 |
4.4 ± 0.6 |
0.94 |
0.03 |
97 |
| Orosomucoid (g/L) |
0.87 ± 0.02 |
0.87 ± 0.04 |
0.93 |
0.03 |
97 |
| Haptoglobin (g/L) |
1.6 ± 0.1 |
1.5 ± 0.1 |
0.46 |
0.11 |
89 |
Mean ± SEM
BMI: body mass index, BP: blood pressure, LDL-C: low density lipoprotein cholesterol, HDL-C: high density lipoprotein cholesterol, apoB: apolipoprotein B, glucose disposal
rate calculated from the hyperinsulinemic euglycemic clamp, hsCRP: high sensitivity C-reactive protein
1whole cohort: n=58, Low GPx activity: n=34, High GPx activity: n=24
2whole cohort: n=57, Low GPx activity: n=32, High GPx activity: n=25
3whole cohort: n=48, Low GPx activity: n=25, High GPx activity: n=23 |
