| |
Control Participants (n=21)
Mean ± S.D. |
Diabetic Participants
(n=153)
Mean ± S.D. |
P
Value |
95% Confidence
Interval |
| Age (years) |
13.20 ± 3.17 |
12.95 ± 3.51 |
0.757 |
(-1.35, 1.85) |
| Free Carnitine (µmol/L) |
28.92 ± 7.42 |
32.32 ± 9.44 |
0.115 |
(-7.64, 0.84) |
| Total Carnitine (µmol/L) |
33.78 ± 7.76 |
36.80 ± 10.76 |
0.216 |
(-7.82, 1.78) |
| Calculated acyl Carnitine (µmol/L) (total-free) |
4.86 ± 2.70 |
4.48 ± 3.48 |
0.632 |
(-1.18, 1.94) |
Calculated acyl:free ratio
|
0.20 ± 0.14 |
0.15 ± 0.14 |
0.127 |
(-0.01, 0.11) |
Free carnitine/C16 + C18
(CPT-1 activity) |
0.20 ± 0.09 |
0.28 ± 0.11 |
0.002* |
(-0.13, -0.03) |
| C3 (nmol/L) |
104.44 ± 44.70 |
127.44 ± 61.18 |
0.099 |
(-50.33, 4.33) |
| C3-DC (nmol/L) |
44.75 ± 18.89 |
37.16 ± 19.61 |
0.097 |
(-1.38, 16.56) |
| C4 (nmol/L) |
121.64 ± 45.85 |
121.73 ± 72.18 |
0.996 |
(-32.08, 31.90) |
| C5 (nmol/L) |
185.26 ± 55.99 |
177.25 ± 127.21 |
0.777 |
(-47.62, 63.64) |
| C5-DC (nmol/L) |
31.63 ± 12.40 |
37.54 ± 18.22 |
0.152 |
(-14.01, 2.19) |
| C6(nmol/L) |
73.82 ± 24.18 |
65.42 ± 32.23 |
0.252 |
(-6.02, 22.82) |
| C8(nmol/L) |
62.45 ± 20.57 |
84.36 ± 41.46 |
0.019* |
(-40.10, -3.72) |
| C10(nmol/L) |
96.07 ± 34.97 |
130.04 ± 65.89 |
0.022* |
(-62.94, -5.00) |
| C10:1 (nmol/L) |
139.13 ± 52.04 |
134.05 ± 51.84 |
0.674 |
(-18.74, 28.90) |
| C12(nmol/L) |
75.09 ± 18.07 |
75.45 ± 37.51 |
0.966 |
(-16.80, 16.08) |
| C12:1 (nmol/L) |
90.82 ± 30.45 |
79.32 ± 42.55 |
0.233 |
(-7.48, 30.48) |
| C14(nmol/L) |
39.09±10.33 |
38.22 ± 24.05 |
0.870 |
(-9.64, 11.38) |
| C14:1 (nmol/L) |
56.01 ±17.13 |
69.23 ± 38.11 |
0.119 |
(-29.89, 3.45) |
| C16(nmol/L) |
79.29 ±15.05 |
62.21 ± 21.27 |
< 0.001* |
(7.60, 26.56) |
| C16:1 (nmol/L) |
53.08 ± 17.56 |
46.61 ± 22.08 |
0.200 |
(-3.45, 16.39) |
| C16-OH (nmol/L) |
17.87 ± 4.21 |
11.41 ± 11.31 |
0.011* |
(1.53, 11.39) |
| C18(nmol/L) |
73.23 ±27.99 |
64.37 ± 25.96 |
0.148 |
(-3.18, 20.90) |
| C18:1 (nmol/L) |
128.17 ± 39.53 |
130.81 ± 53.07 |
0.827 |
(-26.38, 21.10) |
| C18-OH (nmol/L) |
13.67 ± 6.70 |
36.78 ± 76.71 |
0.171 |
(-56.25, 10.03) |
| C18:1-OH (nmol/L) |
17.39 ± 6.64 |
9.65 ± 3.99 |
<0.001* |
(5.73, 9.75) |
*significantly different from controls |
