Drug N Fasting Postprandial Before Treatment Total Ghrelin   NA 46 386±37 329±34a Active Ghrelin   NA 46 160±18 132±19a 1 wk after treatment Total Ghrelin   Metformin 16 297±77b 267±71b    Metformin+ Sitagliptin 15 352±67 269±79ab  Sitagliptin 15 420±78 345±73ab Active Ghrelin  Metformin 15 148±43bc 115±32abc  Metformin+Sitagliptin 15 177±45c 107±22abc  Sitagliptin 14 113±23b 85±12ab *Statistics is computed on weighted mean multiple comparison (ANOVA) ap<0.05; postprandial versus fasting bp<0.05; after medication versus corresponding value before medication cp<0.05; medication versus sitagliptin alone

Table 2: Total and active ghrelin levels (pg/mL) before and after treatment (mean±SEM)*.