Metabolic TCF7L2-rs290487 P
Value*
13q31.1-rs1359790 P
Value*
CDKAL1-rs9465871 P
Value*
factors† TT CT CC AA AG GG TT CT CC
Men, N  122  134  31   26   114  141    58 145  86   
FPG, mmol/L 5.4(1.2) 5.3(1.2) 5.3(1.1) 0.800 5.3(1.2) 5.3(1.1) 5.4(1.2) 0.583 5.1(1.1) 5.4(1.2) 5.5(1.2) 0.072
HbA1c, % 5.9(1.1) 5.9(1.1) 5.8(1.1) 0.757 5.9(1.1) 5.9(1.1) 5.9(1.1) 0.887 5.8(1.1) 5.9(1.1) 5.9(1.1) 0.384
TC, mmol/L 4.2(1.2) 4.3(1.2) 4.3(1.2) 0.461 4.3(1.2) 4.3(1.2) 4.2(1.2) 0.497 4.1(1.2) 4.3(1.2) 4.3(1.2) 0.222
TG, mmol/L 1.3(1.8) 1.4(1.7) 1.1(1.8) 0.209 1.2(1.6) 1.3(1.8) 1.3(1.8) 0.933 1.3(1.8) 1.3(1.8) 1.4(1.7) 0.672
LDLC, mmol/L 2.6(1.3) 2.7(1.3) 2.7(1.3) 0.543 2.6(1.3) 2.7(1.3) 2.6(1.3) 0.502 2.5(1.4) 2.7(1.3) 2.6(1.3) 0.135
HDLC, mmol/L 1.1(1.3) 1.1(1.3) 1.1(1.2) 0.952 1.2(1.3) 1.1(1.2) 1.1(1.3) 0.101 1.1(1.3) 1.1(1.3) 1.1(1.3) 0.979
BMI 25.2(1.1) 24.8(1.1) 24.5(1.1) 0.504 25.9(1.1) 24.7(1.1) 25.0(1.1) 0.224 24.9(1.2) 24.9(1.1) 25.0(1.1) 0.983
WHR 0.88(1.1) 0.88(1.1) 0.88(1.1) 0.936 0.90(1.1) 0.88(1.1) 0.88(1.1) 0.353 0.88(1.1) 0.88(1.1) 0.88(1.1) 0.873
Women, N 245 283 81   41 244 321   140 298 179  
FPG, mmol/L 5.2(1.2) 5.3(1.2) 5.3(1.2) 0.806 5.3(1.1) 5.3(1.2) 5.2(1.2) 0.846 5.2(1.1) 5.3(1.2) 5.3(1.2) 0.261
HbA1c, % 5.9(1.1) 6.0(1.1) 6.0(1.1) 0.545 6.0(1.1) 6.0(1.1) 6.0(1.1) 0.872 5.9(1.1) 6.0(1.1) 6.1(1.1) 0.025
TC, mmol/L 4.6(1.2) 4.5(1.2) 4.5(1.2) 0.765 4.5(1.3) 4.6(1.2) 4.5(1.2) 0.757 4.7(1.2) 4.5(1.2) 4.5(1.2) 0.034
TG, mmol/L 1.2(1.7) 1.2(1.7) 1.3(1.6) 0.578 1.2(1.6) 1.3(1.7) 1.2(1.6) 0.575 1.3(1.7) 1.2(1.7) 1.2(1.7) 0.108
LDLC, mmol/L 2.8(1.3) 2.8(1.3) 2.8(1.4) 0.914 2.8(1.4) 2.8(1.3) 2.8(1.3) 0.894 2.9(1.3) 2.8(1.3) 2.8(1.3) 0.121
HDLC, 1.3(1.3) 1.3(1.3) 1.3(1.3) 0.391 1.3(1.2) 1.3(1.3) 1.3(1.3) 0.784 1.3(1.3) 1.3(1.3) 1.3(1.3) 0.712
BMI 24.4(1.1) 25.0(1.1) 25.0(1.1) 0.106 25.4(1.1) 24.8(1.1) 24.8(1.1) 0.374 25.2(1.1) 24.7(1.1) 24.6(1.1) 0.293
WHR 0.84(1.1) 0.84(1.1) 0.83(1.1) 0.525 0.85(1.1) 0.84(1.1) 0.83(1.1) 0.219 0.83(1.1) 0.84(1.1) 0.84(1.1) 0.491
† Continuous variables were expressed as Mean (S.D.)
* Generalized linear model adjusted age.  
Table 3: Average level of metabolic factors by genotypes of TCF7L2-rs290487, rs1359790 at 13q31.1 and CDKAL1-rs9465871.