Figure 2: Stimulatory effects of S43126 on insulin release from Min6 cells. S43126 [10-5M] at 5mins induced the highest insulin release (2.3 fold) and 3.1 fold under conditions of (A) low glucose ( 2.8 mM) and (B) high glucose (16.8 mM) respectively, relative to control. (A) Data are presented as mean percent change +/- standard error from three separate experiments run in duplicate. (a= ***p< 0.001 same time point, compared to [10-7M] and b= ***p< 0.001 same dose, different time compared to 5mins, ANOVA) (B) Data are presented as mean percent change +/- standard error from three separate experiments run in duplicate. (a= **p< 0.01, ***p< 0.001 same time point, compared to [10-7M] b= **p< 0.01, ***p< 0.001 same dose, different time compared to 5 mins, two-way ANOVA).