Figure 3: Effects of Efaroxan (E) on S43126(S)-induced insulin release. I1-imidazoline receptor antagonist Efaroxan) [100 μM] attenuated the insulinotropic response of Min6 cells to S41326 under (2A) low and (2B) high glucose. (2A) Data are presented as mean percent change +/- standard error from three separate experiments run in duplicate. (a= **p< 0.01, ***p< 0.001 same time point, compared to E and b= ***p< 0.001 same dose, different time compared to 5 mins, ANOVA). (2B) Data are presented as mean percent change +/- standard error from three separate experiments run in duplicate. (a= ***p< 0.001 same time point, compared to E and b= ***p< 0.001 same dose, different time compared to 5 mins, two-way ANOVA).