All

SUDOSCAN risk score

P-value

P-value adjusted*

Risk score        ≤ 25

Risk score   ]25-50]

Risk score       > 50

N

232

44

149

39

 

 

Men participants

140 (60%)

31 (70%)

90 (60%)

19 (49%)

0.130

-

Diabetes duration (years)

9 ± 7

4 ± 4

9 ± 6

15 ± 7

< 0.001

-

BMI (kg/m2)

26 ± 4

24 ± 3

26 ± 3

29 ± 4

< 0.001

-

Age (years)

52 ± 9

44 ± 8

53 ± 8

59 ± 7

< 0.001

-

HbA1C  (%)

8.5 ± 1. 8

7.4 ± 1. 8

8.3 ± 1. 5

10.3 ± 1.7

< 0.001

< 0.001

SBP (mmHg)

120 ± 16

117 ± 16

119 ± 16

127 ± 16

0.011

NS

DBP (mmHg)

76 ± 8

77 ± 10

76 ± 8

77 ± 7

NS

NS

ESC hands (µS)

59 ± 20

72 ± 18

58 ± 19

46 ± 18

< 0.001

< 0.001

ESC feet (µS)

59 ± 21

77 ± 10

58 ± 19

43 ± 20

< 0.001

< 0.001

HR variability at rest

 

     

 

 

Heart Rate (bpm)

78 ± 11

77 ± 11

77 ± 11

81 ± 11

NS

NS

SDNN (ms)

35 ± 18

39 ± 18

36 ± 18

28 ± 18

0.001

NS

RMSSD (ms)

24 ± 20

28 ± 26

24 ± 18

20 ± 21

0.044

NS

TP (ms2)

1353 ± 1410

1688 ± 1447

1385 ± 1428

851 ± 1168

< 0.001

0.036

VLF (ms2)

699 ± 752

915 ± 849

701 ± 751

442 ± 549

< 0.001

0.098

LF (ms2)

355 ± 423

392 ± 317

384 ± 470

200.0 ± 285

< 0.001

0.079

HF (ms2)

 221 ± 371

 260 ± 442

 228 ± 359

 148 ± 322

0.002

0.047

LF/HF

2.8 ± 2.3

3.1 ± 2.3

2.7 ± 2.2

2.9 ± 2.4

NS

NS

HR variability during moderate activity

 

     

 

 

Heart Rate (bpm)

93± 11

92 ± 12

92 ± 11

97 ± 10

0.017

NS

SDNN (ms)

70 ± 27

76± 27

69 ± 27

66 ± 24

NS

NS

RMSSD (ms)

20 ± 16

24 ± 18

19 ± 12

19 ± 25

0.020

NS

TP (ms2)

1477 ± 1373

2059 ± 1591

1444 ± 1336

942 ± 975

< 0.001

NS

VLF (ms2)

964 ± 932

1300 ± 997

957 ± 943

611 ± 657

< 0.001

NS

LF (ms2)

295 ± 299

449 ± 325

289 ± 299

142 ± 162

< 0.001

0.019

HF (ms2)

 107 ± 228

 172 ± 415

 104 ± 166

45 ± 74

< 0.001

0.034

LF/HF

4.8 ± 3.1

5.2 ± 3.1

4.6 ± 3.1

4.9 ± 3.2

NS

NS

CARTs

 

     

 

 

Abnormal E:I ratio (< 1.21)

46 (20%)

6 (14%)

26 (17%)

14 (36%)

0.027

0.028

Abnormal 30:15 ratio (< 1.03)

71 (31%)

5 (11%)

44 (30%)

22 (56%)

< 0.001

< 0.001

Orthostatic hypotension (> 20 mmHg)

17 (7%)

3 (7%)

10 (7%)

4 (10%)

NS

NS

Data are means ± SD

           

*P-value adjusted on gender, diabetes duration and BMI

Table 3: Demographic, HRV and CARTs characteristics according to SUDOSCAN risk score values.