Gene |
Risk Allele Freq in
Controls |
OR/Beta [95% CI] |
P-Value |
First Author. Journal; Published Year |
SNP |
Gene |
Region |
Population |
Trait |
|
|
|
|
rs10923931 |
NOTCH2, ADAM30 |
1p12 |
European |
T2D |
T[0.11] |
1.13[1.08-1.17] |
4x10-8 |
Zeggini et al. Nat Genet; 2008 |
rs243021 |
BCL11A |
2p16.1 |
European |
T2D |
A[NR] |
1.08[1.06-1.10] |
3x10-15 |
Voight et al. Nat Genet; 2010 |
rs7578326 |
IRS1 |
2q36.3 |
European |
T2D |
A[NR] |
1.11[1.08-1.13] |
5x10-20 |
Voight et al. Nat Genet; 2010 |
rs2943641 |
LOC64673, IRS1 |
2q36.3 |
European |
T2D/Other traits |
C[0.63] |
1.19[1.13-1.25] |
9x10-12 |
Rung et al. Nat Genet; 2009 |
rs7593730 |
RBMS1, ITGB6 |
2q24.2 |
European |
T2D |
?[0.78] |
1.11[1.08-1.16] |
4x10-8 |
Qi et al. Hum Mol Genet; 2010 |
rs7578597 |
THADA |
2p21 |
European |
T2D |
T[0.9] |
1.15[1.10-1.20] |
1x10-9 |
Zeggini et al. Nat Genet; 2008 |
rs4607103 |
ADAMTS9 |
3p14.1 |
European |
T2D |
C[0.76] |
1.09[1.06-1.12] |
1x10-8 |
Zeggini et al. Nat Genet; 2008 |
rs4402960 |
IGF2BP2 |
3q27.2 |
European |
T2D |
T[0.3] |
1.14[1.11-1.18] |
9x10-16 |
Scott et al. Science; 2007 |
rs358806 |
NR |
3p14 |
European |
T2D |
?[0.8] |
1.16[1.03-1.33] |
3x10-6 |
WTCC Consortium Nature; 2007 |
rs1801282 |
PPARG |
3p25.2 |
European |
T2D |
C[0.82] |
1.14[1.08-1.20] |
2x10-6 |
Scott et al. Science; 2007 |
rs17036101 |
SYN2, PPARG |
3p25.2 |
European |
T2D |
G[0.93] |
1.15[1.10-1.21] |
2x10-7 |
Zeggini et al. Nat Genet; 2008 |
rs1801214 |
WFS1 |
4p16.1 |
European |
T2D |
T[NR] |
1.13[1.08-1.18] |
3x10-8 |
Voight et al. Nat Genet; 2010 |
rs4689388 |
WFS1, PPP2R2C |
4p16.1 |
European |
T2D/Other traits |
T[0.57] |
1.16[1.10-1.21] |
1x10-8 |
Rung et al. Nat Genet; 2009 |
rs12518099 |
LOC72901, CETN3 |
5q14.3 |
European |
T2D/Other traits |
C[0.23] |
1.16[1.10-1.22] |
7x10-7 |
Rung et al. Nat Genet; 2009 |
rs4457053 |
ZBED3 |
5q13.3 |
European |
T2D |
G[NR] |
1.08[1.06-1.11] |
3x10-12 |
Voight et al. Nat Genet; 2010 |
rs7754840 |
CDKAL1 |
6p22.3 |
European |
T2D |
C[0.36] |
1.12[1.08-1.16] |
4x10-11 |
Scott et al. Science; 2007 |
rs896854 |
TP53INP1 |
6q22.1 |
European |
T2D |
T[NR] |
1.06[1.04-1.09] |
1x10-9 |
Voight et al. Nat Genet; 2010 |
rs9472138 |
VEGFA |
6p21.1 |
European |
T2D |
T[0.28] |
1.06[1.04-1.09] |
4x10-6 |
Zeggini et al. Nat Genet; 2008 |
rs864745 |
JAZF1 |
7p15.1 |
European |
T2D |
T[0.5] |
1.1[1.07-1.13] |
5x10-14 |
Zeggini et al. Nat Genet; 2008 |
rs972283 |
KLF14 |
7q32.3 |
European |
T2D |
G[NR] |
1.07[1.05-1.10] |
2x10-10 |
Voight et al. Nat Genet; 2010 |
rs13266634 |
SLC30A8 |
8q24.11 |
European |
T2D |
C[0.61] |
1.12[1.07-1.16] |
5x10-8 |
Scott et al. Science; 2007 |
rs564398 |
CDKN2A, CDKN2B |
9p21.3 |
European |
T2D |
T[0.56] |
1.13[1.08-1.19] |
1x10-6 |
Zeggini et al. Science; 2007 |
rs7018475 |
CDKN2B |
9p21.3 |
European |
T2D |
?[NR] |
1.35[1.18-1.56] |
3x10-8 |
Huang J et al. Eur J Hum Genet; 2012 |
rs13292136 |
CHCHD9 |
9q21.31 |
European |
T2D |
C[NR] |
1.11[1.07-1.15] |
3x10-8 |
Voight et al. Nat Genet; 2010 |
rs12779790 |
CDC123,CAMK1D |
10p13 |
European |
T2D |
G[0.18] |
1.11[1.07-1.14] |
1x10-10 |
Zeggini et al. Nat Genet; 2008 |
rs1111875 |
HHEX |
10q23.33 |
European |
T2D |
C[0.52] |
1.13[1.09-1.17] |
6x10-10 |
Scott et al. Science; 2007 |
rs7903146 |
TCF7L2 |
10q25.2 |
European |
T2D |
T[0.26] |
1.38[1.31-1.46] |
2x10-31 |
Saxena et al. Science; 2007 |
rs1552224 |
ARAP1 |
11q13.4 |
European |
T2D |
A[NR] |
1.14[1.11-1.17] |
1x10-22 |
Voight et al. Nat Genet; 2010 |
rs5219 |
KCNJ11 |
11p15.1 |
European |
T2D |
T[0.46] |
1.14[1.10-1.19] |
7x10-11 |
Scott et al. Science; 2007 |
rs231362 |
KCNQ1 |
11p15.5 |
European |
T2D |
G[NR] |
1.08[1.06-1.10] |
3x10-13 |
Voight et al. Nat Genet; 2010 |
rs1387153 |
MTNR1B |
11q14.3 |
European |
T2D |
T[NR] |
1.09[1.06-1.11] |
8x10-15 |
Voight et al. Nat Genet; 2010 |
rs1153188 |
DCD |
12q13.2 |
European |
T2D |
A[0.73] |
1.08[1.05-1.11] |
2x10-7 |
Zeggini et al. Nat Genet; 2008 |
rs1531343 |
HMGA2 |
12q14.3 |
European |
T2D |
C[NR] |
1.1[1.07-1.14] |
4x10-9 |
Voight et al. Nat Genet; 2010 |
rs7957197 |
HNF1A |
12q24.31 |
European |
T2D |
T[NR] |
1.07[1.05-1.10] |
2x10-8 |
Voight et al. Nat Genet; 2010 |
rs7961581 |
TSPAN8, LGR5 |
12q21.1 |
European |
T2D |
C[0.27] |
1.09[1.06-1.12] |
1x10-9 |
Zeggini et al. Nat Genet; 2008 |
rs8042680 |
PRC1 |
15q26.1 |
European |
T2D |
A[NR] |
1.07[1.05-1.09] |
2x10-10 |
Voight et al. Nat Genet; 2010 |
rs11634397 |
ZFAND6 |
15q25.1 |
European |
T2D |
G[NR] |
1.06[1.04-1.08] |
2x10-9 |
Voight et al. Nat Genet; 2010 |
rs8050136 |
FTO |
16q12.2 |
European |
T2D |
A[0.4] |
1.23[1.18-1.32] |
7x10-14 |
Zeggini et al. Science; 2007 |
rs4430796 |
HNF1B |
17q12 |
European |
T2D |
G[NR] |
1.14[1.08-1.20] |
2x10-6 |
Voight et al. Nat Genet; 2010 |
rs5945326 |
DUSP9 |
Xq26 |
European |
T2D |
G[NR] |
1.27[1.18-1.37] |
3x10-10 |
Voight et al. Nat Genet; 2010 |
rs7542900 |
SLC44A3, F3 |
1p21.3 |
African Amer. |
T2D |
C[0.56] |
1.16[1.09-1.25] |
6x10-6 |
Palmer ND et al. PLoS One; 2012 |
rs7560163 |
RBM43, RND3 |
2q23.3 |
African Amer. |
T2D |
C[0.86] |
1.33[1.19-1.49] |
7x10-9 |
Palmer ND et al. PLoS One; 2012 |
rs2722769 |
GALNTL4, LOC729013 |
11p15.3 |
African Amer. |
T2D |
C[0.53] |
1.35[1.19-1.54] |
2x10-6 |
Palmer ND et al. PLoS One; 2012 |
rs7107217 |
TMEM45B, BARX2 |
11q24.3 |
African Amer. |
T2D |
C[0.91] |
1.18[1.10-1.27] |
3x10-7 |
Palmer ND et al. PLoS One; 2012 |
rs17045328 |
CR2 |
1q32.2 |
Asian |
T2D |
G[0.3] |
1.38[1.20-1.59] |
7x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs12027542 |
PCNXL2 |
1q42.2 |
Asian |
T2D |
A[0.61] |
1.41[1.23-1.61] |
4x10-7 |
Sim X et al. PLoS Genet; 2011 |
rs7630877 |
PEX5L |
3q26.33 |
Asian |
T2D |
A[0.17] |
1.32[1.17-1.49] |
7x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs3773506 |
PLS1 |
3q23 |
Asian |
T2D |
C[0.06] |
1.81[1.39-2.35] |
9x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs831571 |
PSMD6 |
3p14.1 |
Asian |
T2D |
c[0.61] |
1.09[1.06-1.12] |
8x10-11 |
Cho YS et al. Nat Genet; 2011 |
rs2063640 |
ZPLD1 |
3q12.3 |
Asian |
T2D |
A[0.17] |
1.23[1.13-1.34] |
3x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs6815464 |
MAEA |
4p16.3 |
Asian |
T2D |
C[0.58] |
1.13[1.10-1.16] |
2x10-20 |
Cho YS et al. Nat Genet; 2011 |
rs1048886 |
C6orf57 |
6q13 |
Asian |
T2D |
G[0.18] |
1.54[1.32-1.80] |
3x10-8 |
Sim X et al. PLoS Genet; 2011 |
rs1535500 |
KCNK16 |
6p21.2 |
Asian |
T2D |
T[0.42] |
1.08[1.05-1.11] |
2x10-8 |
Cho YS et al. Nat Genet; 2011 |
rs9470794 |
ZFAND3 |
6p21.2 |
Asian |
T2D |
C[0.27] |
1.12[1.08-1.16] |
2x10-10 |
Cho YS et al. Nat Genet; 2011 |
rs7636 |
ACHE |
7q22.1 |
Asian |
T2D |
A[0.06] |
1.85[1.42-2.41] |
5x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs6467136 |
GCC1,PAX4 |
7q32.1 |
Asian |
T2D |
G[0.79] |
1.11[1.07-1.14] |
5x10-11 |
Cho YS et al. Nat Genet; 2011 |
rs7041847 |
GLIS3 |
9p24.2 |
Asian |
T2D |
A[0.41] |
1.1[1.07-1.13] |
2x10-14 |
Cho YS et al. Nat Genet; 2011 |
rs17584499 |
PTPRD |
9p24.1 |
Asian |
T2D |
T[0.06] |
1.57[1.36-1.82] |
9x10-10 |
Tsai et al. PLoS Genet; 2010 |
rs6583826 |
KIF11 |
10q23.33 |
Asian |
T2D |
G[0.26] |
1.18[1.10-1.27] |
7x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs10741243 |
TCERG1L |
10q26.3 |
Asian |
T2D |
G[0.93] |
1.75[1.38-2.23] |
5x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs1359790 |
SPRY2 |
13q31.1 |
Asian |
T2D |
G[0.71] |
1.15[1.10-1.20] |
6x10-9 |
Shu et al. PLoS Genet; 2010 |
rs1436955 |
C2CD4B |
15q22.2 |
Asian |
T2D |
C[0.73] |
1.13[1.08-1.19] |
7x10-7 |
Shu et al. PLoS Genet; 2010 |
rs16955379 |
CMIP |
16q23.2 |
Asian |
T2D |
C[0.8] |
1.08[1.05-1.12] |
3x10-7 |
Cho YS et al. Nat Genet; 2011 |
rs17797882 |
WWOX |
16q23.2 |
Asian |
T2D |
T[0.32] |
1.08[1.05-1.12] |
9x10-7 |
Cho YS et al. Nat Genet; 2011 |
rs391300 |
SRR |
17p13.3 |
Asian |
T2D |
G[0.62] |
1.28[1.18-1.39] |
3x10-9 |
Tsai et al. PLoS Genet; 2010 |
rs10460009 |
LPIN2 |
18p11.31 |
Asian |
T2D |
C[0.6] |
1.35[1.18-1.54] |
9x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs472265 |
PAPL |
19q13.2 |
Asian |
T2D |
G[0.22] |
1.39[1.20-1.61] |
9x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs3786897 |
PEPD |
19q13.11 |
Asian |
T2D |
A[0.56] |
1.1[1.07-1.14] |
1x10-8 |
Cho YS et al. Nat Genet; 2011 |
rs2833610 |
HUNK |
21q22.11 |
Asian |
T2D |
A[0.57] |
1.17[1.09-1.24] |
4x10-6 |
Sim X et al. PLoS Genet; 2011 |
rs3923113 |
GRB14 |
2q24.3 |
South Asian |
T2D |
A[0.74] |
1.09[1.06-1.13] |
1x10-8 |
Kooner JS et al. Nat Genet; 2011 |
rs16861329 |
ST6GAL1 |
3q27.3 |
South Asian |
T2D |
G[0.75] |
1.09[1.06-1.12] |
3x10-8 |
Kooner JS et al. Nat Genet; 2011 |
rs1802295 |
VPS26A |
10q22.1 |
South Asian |
T2D |
A[0.26] |
1.08[1.05-1.12] |
4x10-8 |
Kooner JS et al. Nat Genet; 2011 |
rs2028299 |
AP3S2 |
15q26.1 |
South Asian |
T2D |
C[0.31] |
1.1[1.07-1.13] |
2x10-11 |
Kooner JS et al. Nat Genet; 2011 |
rs7178572 |
HMG20A |
15q24.3 |
South Asian |
T2D |
G[0.52] |
1.09[1.06-1.12] |
7x10-11 |
Kooner JS et al. Nat Genet; 2011 |
rs4812829 |
HNF4A |
20q13.12 |
South Asian |
T2D |
A[0.29] |
1.09[1.06-1.12] |
3x10-10 |
Kooner JS et al. Nat Genet; 2011 |
rs2237897 |
KCNQ1 |
11p15.4 |
Japanese |
T2D |
C[0.61] |
1.33[1.24-1.41] |
1x10-16 |
Unoki et al. Nat Genet; 2008 |
rs2237892 |
KCNQ1 |
11p15.5 |
Japanese |
T2D |
C[0.61] |
1.4[1.34-1.47] |
2x10-42 |
Yasuda et al. Nat Genet; 2008 |
rs7172432 |
C2CD4A,C2CD4B |
15q22.2 |
Japanese |
T2D |
?[0.58] |
1.11[1.08-1.14] |
9x10-14 |
Yamauchi et al. Nat Genet; 2010 |
rs730570 |
C14orf70 |
14q32.2 |
Mexican |
T2D |
G[NR] |
1.14[1.08-1.21] |
8x10-6 |
Parra EJ et al. Diabetologia; 2011 |
