Table 1

Transporter	IC₅₀ (mM)				Probe Substrate
Transporter	Remogliflozin Etabonate	Remogliflozin	GSK279782	GSK333081	Probe Substrate
Pgp	>100	>100	>100	>100	[³H]-digoxin
OATP1B1	5.3 (1.1)^a	25 (2.3)	14 (1.5)	NT	[³H]-estradiol 17β-D-glucuronide
OCT1	43.4 (3.7)	38.6 (1.6)	>100	>100	[¹⁴C]-tetraethylammonium
OCT3	>100	>100	>100	>100	[³H]-histamine

^aData are the mean (± standard deviation) from triplicate wells.
NT: Not Tested

Table 1: Inhibition of Human ABC and SLC Transporters by Remogliflozin etabonate, Remogliflozin and Metabolites.