Accession number (NCBI) Gene description Gene Symbol Enriched functional and pathway annotations (David and Webgestalt) Diabetic environment (Fold change, p<0.05) Diabetic environment and calcitriol (Fold change p<0.05)
NM_004235 Kruppel-like factor 4 KLF4 Cellular metabolic process , ubiquitin-dependent protein catabolic process, intracellular organelle part, transcription repressor activity +1.48 -1.28
NM_000786 Cytochrome P450, family 51, subfamily A CYP51A1 Cellular metabolic process, cytoplasmic and organelle part, metabolic process, steroid biosynthesis, metabolic processes +1.44 -1.72
NM_002983 Chemokine (C-C motif) ligand 3 CCL3 Chemokine signaling pathway, Toll-like receptor signaling pathway, Cytokine-cytokine receptor interaction +1.48 -1.37
NM_004064 Cyclin-dependent kinase inhibitor 1B CDKN1B cellular metabolic process, cell cycle process, regulation of cell proliferation, pathways in cancer, +1.26 -1.48
NM_032731 Thioredoxin domain containing 17 TXNDC17 Oxidoreductase activity, intracellular part, cytoplasm, nitrogen compound metabolic process, protein binding +1.39 -1.26
NM_003921 B-cell CLL/lymphoma 10 BCL10 Apoptosis, cellular process, negative regulation of cell growth, positive regulation of biological process +1.46 -1.33
NM_001731 B-cell translocation gene 1, anti-proliferative BTG1 Endothelial cell differentiation, endothelium development, negative regulation of cell growth, transcription regulator activity +1.59 -1.39
NM_002609 Platelet-derived growth factor receptor, beta polypeptide PDGFRB Multicellular organismal development, enzyme linked receptor protein signaling pathway, system development, regulation of protein modification process, cell motion -1.65 +1.35
NM_005902 SMAD family member 3 SMAD3 Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) -1.24 +1.2 (p=0.08)
NM_005228 Epidermal growth factor receptor EGFR Biological adhesion, multicellular organismal development, developmental process, positive regulation of molecular, cellular and biological process, cell cycle process -1.39 +1.4
NM_006129 Bone morphogenetic protein 1 BMP1 Cell and biological adhesion, skeletal system development, metabolism of lipids and lipoproteins, calcium ion binding -1.26 +1.32
NM_001846 Collagen, type IV, alpha 2 COL4A2 Extracellular matrix part, ECM-receptor interaction, collagen, multicellular organismal development, anatomical structure morphogenesis -1.59 +1.32
NM_000201 Intercellular adhesion molecule 1 ICAM1 Cell and biological adhesion, positive regulation of molecular, cellular and biological process, cell motion -1.27 +1.33
NM_006472 Thioredoxin interacting protein TXNIP Cellular metabolic process, intracellular organelle part, cellular biosynthetic process, regulation of metabolic process +10.02 -1.4 (p=0.6 )
NM_005655 Kruppel-like factor 10 KLF10 Cellular metabolic process, mitotic cell cycle, nitrogen compound metabolic process, negative regulation of macromolecule metabolic process, negative regulation of cellular metabolic process +1.65

-1.8 (p=0.2)

NM_003597 Kruppel-like factor 11 KLF11 Cellular metabolic process, negative regulation of macromolecule metabolic process, negative regulation of cellular metabolic process +1.69 -1.2 (p=0.39 )
NM_001042454 Transforming growth factor beta 1 induced TGFB1I1 Focal adhesion, enzyme linked receptor protein signaling pathway, protein kinase activity, multicellular organismal development -1.41 +1.09 (p=0.54)
NM_003701 Tumor necrosis factor (ligand superfamily) TNFSF11
RANKL
Cytokine-cytokine receptor interaction, osteoclast differentiation rheumatoid arthritis -1.21 -1.02 (p=0.7)
NM_002546 Tumor necrosis factor receptor superfamily TNFRSF11B
OPG
Cytokine-cytokine receptor interaction, osteoclast differentiation +1.11 (p=0.26) +1.19 (p=0.07)
Table 1: Genes differentially regulated by a diabetic environment (200 μg/ml AGE-HSA and 250 mg/dl glucose) and 10-10 mol/l calcitriol.