Variable (Diabetic Range) Thiamine Treatment Placebo
  Baseline Therapy Washout Baseline Therapy Washout
Creatine Kinase U/L(M:38-174; F:96-140) 81.85±52.30 86.20±62.04g 141.90±114.20id 69.95 ± 55.35 58.30 ± 37.19g 75.85±42.78
Uric acid mg/dl(3.5-8.5) 4.65±10.05 3.75±1.49h 4.82±1.47e 3.99±1.09 40.03±1.70 4.45±0.93
Blood Urea Nitrogen mg/dl (7-21) 11.70 ± 4.87 12.45 ± 5.24 140.05 ±4.76d 12.25±2.24 9.9 ±4.59d,g 14.8 ±5.92d
GFR (ml/min) (<60 chronic renal disease) 85 ±19 90±30 77 ±20 93 ± 23 97± 18 87± 21 P’<0.05, P”<0.01
Serum creatinine mg/dl) (0.8-1.4) 0.915±0.195 0.84±0.28g 0.95±0.25 0.84±0.24 0.77 ± 0.20i 0.94±0.21
Urine creatinine (mg/dl) (30-125) 42.4±25.63 45.86±31.14 43.73±37.37 42.65±31.76 59.1±41.37d 66.59±34.78e
Diastolic BP (mmHg)(<90) 87 ± 7 85 ± 9 87 ± 7 84 ± 6 84 ± 8 83 ± 7
Systolic BP (mmHg)(<140) 126 ± 14 133 ± 20 135 ± 14
P’<0.05
131 ± 10 130 ± 17 130 ± 13
Table 3: Renal function profile and physiological data before and after three month thiamine treatment and after two month washout period.