Lean (n=10) Control (n=10) EX (n=10) EX+in (n=10)
Body mass (g) 308.68.0* 491.6 ± 23.3 352.6 ± 10.6* 436.7 ± 7.2

Fasting glucose(mmol/l)

8.8 ± 1.1* 17.3 ± 4.1 13.4 ± 2.3* 14.8 ± 5.1

Fasting insulin (pmol/l)

5.42 ± 1.0* 12.2 ± 2.2 8.41 ± 1.8* 13.5 ± 1.5

CS activity (μmol/g/min)

13.7 ± 1.2 9.09 ± 1.3 21.8 ± 2.0* 19.2 ± 2.2*

Tissue Weight (g/body weight)

 Gastrocnemius muscle

3.24 ± 0.63* 2.65 ± 0.81 4.12 ± 0.52* 3.46 ± 0.66*

 Soleus muscle

0.46 ± 0.03* 0.26 ± 0.02 0.36 ± 0.05* 0.23 ± 0.04

 Abdominal fat

4.49 ± 1.13* 15.28 ± 1.54 14.0 ± 2.21* 14.6 ± 1.43
CS: Citrate Synthase
EX: Exercise Training
EX+ in: Exercise training + 5α-reductase inhibitor administration
* p<0.01, vs. Zucker-control
p<0.01, vs. Zucker-EX
p<0.01, vs. Zucker-EX + in
Table 1: Animal characteristics.