| ↓Protein name |
↓Gene name |
↓Change in expression |
↓Microarray experiment |
| ↓Aldolasea A and B |
↓ALDOA, ALDOB |
↓↑ |
↓ |
| ↓ATP synthasea beta subunit |
↓ATP5D |
↓↑ |
↓ |
| ↓Cytochrome c oxidase subunit Vib |
↓COX6B |
↓↓ |
↓↑ |
| ↓Dimethyl arginine dimethyl aminohydrolase |
↓DDAH1 |
↓↓ |
↓↓ |
| ↓Enolasea 1 |
↓ENO1 |
↓M |
↓↑ |
| ↓Glyceraldehyde 3 phosphate dehydrogenasea |
↓GAPDH |
↓↑ |
↓↑ |
| ↓Phosphoglycerate kinasea 1 |
↓PGK1 |
↓M |
↓↑ |
| ↓Protein disulfide isomerase |
↓P4HB |
↓↑ |
↓↑ |
| ↓Pyruvate kinase M2 isozyme |
↓PKM2 |
↓M |
↓ |
| ↓Thioredoxin domain 5 isoform 2 |
↓TXNDC5 |
↓↑ |
↓ |
| ↓Triose phosphate isomerase |
↓TPI1 |
↓M |
↓↑ |
Host cell proteins were designated as being downregulated in expression
(↓), upregulated (↑), or modulated (M). aThese host cell proteins also changed
expression in the brains of patients with mild cognitive impairement, early AD, or
AD [369]. It must be noted that T. gondii tachyzoites are thought to rely upon both
glycolysis and the tricarboxylic acid cycle, while bradyzoites are largely dependent
upon glycolysis [364,371]. Although tachyzoites utilize both glycolysis and
oxidative phosphorylation to obtain energy, glycolysis seems to be the predominant
pathway for ATP synthesis in the bradyzoite [372,373]. Moreover, ENO2 and
lactate dehydrogenase1 are only found in tachyzoites, while ENO1 and lactate
dehydrogenase 2 are exclusively expressed in bradyzoites [374,375]. Silencing
of tachyzoite ENO2 altered nuclear targeting of bradyzoite ENO1 in T. gondii
[376,377]. |
