| Tissue |
Pathology |
No treatment |
Treatment with Vit D3 |
| Lung |
Alveolar macrophages |
1 |
0 |
| |
Inflammatory foci |
2 |
1 |
| Liver |
Inflammatory foci |
3 |
2 |
| |
Hemorrhage |
2 |
0 |
| |
Mitosis |
1 |
0 |
| Small intestine |
Inflammatory infiltrates |
1 |
0 |
| |
Necrotic mucosal cells |
2 |
1 |
| Brain |
Presence of the parasite |
2 |
0 |
| Spleen |
Granulocytes |
2 |
1 |
Histopathologic examination of the tissues was performed 7 days post inoculation. Numbers are based on severity of the lesions (0, no lesion, 1, mild, 2, slight, 3, moderate
changes) and the total was divided the number of animals in the group. Also, in vitro studies with incubated intestinal epithelial cells showed a significant dose-dependent
inhibition of intracellular T. gondii tachyzoites (RH strain, type I) proliferation at 10-7 mol/l of 1,25(OH)2D3 concentration |
